Can Obesity Prevalence Explain COVID-19 Indicators (Cases, Mortality, and Recovery)? A Comparative Study in OECD Countries

SARS-CoV-2 virus disease (COVID-19) is declared a global pandemic with multiple risk factors. Obesity is considered by several researchers as one of the serious risk factors for SARS-CoV-2 virus complications based on recent empirical studies. Yet, other scholars argue in favor of the existence of an obesity survival paradox and criticize the former group of studies on the grounds that they lack controls for race, socioeconomic status, or quality of care. The objective of the current study is to analyze the potential relationships between different SARS-CoV-2 virus indicators and obesity on a country-wide level based on an OECD report. In an attempt to test the counterintuitive possibility of an obesity survival paradox, the proposed empirical model relaxes the assumption of monotonic change by applying the quadratic design and testing which one of the two competing models (i.e., quadratic or linear) better fits the data. Findings suggest more complex relationships between SARS-CoV-2 virus indices and obesity rates than previously thought. Consequently, ethical guidelines referring to priority in intubation and intensive care treatments—published by the Israeli Ministry of Health in April 2020—should account for these complex relationships between obesity and SARS-CoV-2 virus. Indeed, there is a linear increase in mortality rate from SARS-CoV-2 virus with an elevated prevalence of obesity. Yet, other indicators, such as the number of infected per 10,00,000 persons, rates of severe SARS-CoV-2 virus cases, rates of recovered SARS-CoV-2 virus patients, and SARS-CoV-2 virus, as the cause of death exhibit quadratic, rather than linear, patterns. The reasons for these nonlinear patterns might be explained by several conditions such as increased metabolic reserves, more aggressive treatment, other non-SARS-CoV-2 virus complications for obese persons, and unidentified factors that should be examined in future research.

Can smoking prevalence explain COVID-19 indicators (cases, mortality, and recovery)? A comparative study in OECD countries.

There are many risk factors associated with the spread of the COVID-19 pandemic, including low wind speed, fossil fuel energy production, air pollution, and smoking. Several studies argue that smoking is not a risk factor for COVID-19 morbidity among males or any other sub-group. The study aims to analyze the following research questions: (1) can smoking prevalence explain COVID-19 indicators (cases, mortality, and recovery)? Are these relationships monotonically increasing or decreasing? In an attempt to test the counter-intuitive possibility of a non-linear relationship, the proposed empirical model relaxes the assumption of monotonic change by applying the quadratic design and testing which one of the two competing models (quadratic or linear) better fits the data. Findings suggest more complex relationships between corona indices and prevalence of smoking than previously thought. These patterns might be explained by several conditions such as the attenuation of hypercytokinemia for mild levels of smoking prevalence compared with non-smokers, elevated social distancing of smokers in countries with lower smoking prevalence, and unidentified factors that should be examined in future research.

Can Increased Recovery Rates from Coronavirus be explained by Prevalence of ADHD? An Analysis at the US Statewide Level.

Previous research demonstrates that ADHD is considered a risk factor for COVID-19. The current study attempts to investigate the relationships between infection, mortality and recovery rates from coronavirus and the prevalence of ADHD at the US statewide level. Based on information from 2011 regarding the prevalence of ADHD across the US by state, findings suggest that, while there are no correlations between ADHD and population size, infection and mortality rates from coronavirus, recovery rates (recovery-population ratio) rise with the prevalence of ADHD. Consequently, a possible explanation is that in coping with the disease, ADHD might provide an evolutionary advantage. An example of this phenomenon can be found in the gene that causes sickle-cell disease, which, as a non-dominant gene, helps cope with infection from malaria. If corroborated, research findings may support the conclusion that coronavirus limitations in special educational frameworks for ADHD would not be required or could be relaxed.JEL Codes: H75, I12.

Do population density, socio-economic ranking and Gini Index of cities influence infection rates from coronavirus? Israel as a case study.

A prominent characteristic of the COVID-19 pandemic is the marked geographic variation in COVID-19 prevalence. The objective of the current study is to assess the influence of population density and socio-economic measures (socio-economic ranking and the Gini Index) across cities on coronavirus infection rates. Israel provides an interesting case study based on the highly non-uniform distribution of urban populations, the existence of one of the most densely populated cities in the world and diversified populations. Moreover, COVID19 challenges the consensus regarding compact planning design. Consequently, it is important to analyze the relationship between COVID19 spread and population density. The outcomes of our study show that ceteris paribus projected probabilities to be infected from coronavirus rise with population density from 1.6 to 2.72% up to a maximum of 5.17-5.238% for a population density of 20,282-20,542 persons per square kilometer (sq. km.). Above this benchmark, the anticipated infection rate drops up to 4.06-4.50%. Projected infection rates of 4.06-4.50% are equal in cities, towns and regional councils (Local Authorities) with the maximal population density of 26,510 and 11,979-13,343 persons per sq. km. A possible interpretation is that while denser cities facilitate human interactions, they also enable and promote improved health infrastructure. This, in turn, contributes to medical literacy, namely, elevated awareness to the benefits associated with compliance with hygienic practices (washing hands), social distancing rules and wearing masks. Findings may support compact planning design principles, namely, development of dense, mixed use, walkable and transit accessible community design in compact and polycentric regions. Indeed, city planners should weigh the costs and benefits of many risk factors, including the COVID19 pandemic.

Do COVID19 infection rates change over time and space? Population density and socio-economic measures as regressors.

The COVID19 pandemic motivated an interesting debate, which is related directly to core issues in urban economics, namely, the advantages and disadvantages of dense cities. On the one hand, compact areas facilitate more intensive human interaction and could lead to higher exposure to the infection, which make them the potential epicenter of the pandemic crisis. On the other hand, dense areas tend to provide superior health and educational systems, which are better prepared to handle pandemics, leading to higher recovery rates and lower mortality rates. The objective of the current study is to test the relationship between COVID19 infection rates (cases÷population) as the dependent variable, and two explanatory variables, population density and socio-economic measures, within two timeframes: May 11, 2020 and January 19, 2021. We use a different methodology to address the relationship between COVID19 spread and population density by fitting a parabolic, instead of a linear, model, while controlling socio-economic indices. We thus apply a better examination of the factors that shape the COVID19 spread across time and space by permitting a non-monotonic relationship. Israel provides an interesting case study based on a highly non-uniform distribution of urban population, and diversified populations. Results of the analyses demonstrate two patterns of change: 1) a significant rise in the median and average infection-population ratio for each level of population density; and 2) a moderate (a steep) rise in infection rates with increased population density on May 11, 2020 (January 19, 2021) for population densities of 4000 to 20,000 persons per square kilometer. The significant rise in the average and median infection-population ratios might be as attributed to the outcome of new COVID19 variants (i.e., the British and the South African mutants), which, in turn, intensify the virus spread. The steeper slope of infection rates and the rise in the standard deviation of the infection-population ratio may be explained by non-uniform spatial distribution of: dissemination of information in a variety of language; different levels of medical infrastructure in different parts of the country; varying levels of compliance to social distancing rules; and strict (limited) compliance to social distancing rules. The last factor of limited compliance might be the outcome of premature optimism due to extensive scope of the vaccination campaign in Israel, which is located in first place globally.